Contents: 1 tube containing 112.5 mg fluralaner and 5.6 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older Specifically designed for the challenges of treating cats, BRAVECTO PLUS delivers everything that you expect from BRAVECTO and more. 0061-5996-02, Bravecto Plus for Cats is a safe and effective topical flea and tick treatment that treats fleas, ticks, gastrointestinal nematodes and prevents heartworm in cats. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. Heartworms were found in the epidural space in the second cat of the 1X group and the cat in the 3X group. Bravecto PLUS Flea,Tick & Worm Spot-On for Cats Large (6.25-12.5kg) Special Price $49.90 $65.00. In two well-controlled laboratory studies, Bravecto Plus was 100% effective against induced heartworm infections when administered 2 months prior to infection. In two well-controlled laboratory studies, Bravecto Plus was 100% effective against induced heartworm infections when administered 2 months prior to infection. Updated The chemical name of moxidectin is (2aE,4E,5’R,6R,6’S,8E,11R,13S,15S,17aR, 20R,20aR,20bS)-6’-[(E)-1,3-Dimethyl-1-butenyl]-5’,6,6’,7,10,11, 14,15,17a,20,20a,20b - dodecahydro - 20,20b - dihydroxy - 5’,6,8,19 - tetramethylspiro[11,15 - methano - 2H,13H,17H - furo[4,3,2 - pq][2,6] benzodioxacyclooctadecin-13,2’-[2H]pyran]-4’,17(3’H)-dione 4’-(E)-(O-methyloxime). The cap should be rotated clockwise or counter clockwise one full turn. No clinical signs associated with liver disease were noted in these cats. It treats and prevents ticks, fleas, heartworms, and several kinds of worms. For topical use only. 0061-5997-02, 0061-5998-01, Show. * Cats over 27.5 lb should be administered the appropriate combination of tubes. Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in cats in foreign markets: polydipsia, swelling of chin and lips, periorbital swelling, blepharospasm, pruritus, erythema, aggression, agitation, pyrexia, mydriasis, hypersalivation, hyperactivity, alopecia, and excessive grooming. In foreign market experience reports for Bravecto Plus, one veterinarian experienced tingling and numbness of the fingers, hand, and arm, and swelling of the hand and arm after getting Bravecto Plus on her fingers. this version. 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. However, for indoor cats, Bravecto’s treatment is still a three-month preventative. Get Label RSS Feed, Treated kittens had reduced food consumption on the day of treatment. Do not contact or allow children to contact the application site until 2 hours post application. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. Do not eat, drink or smoke while handling the product. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. How to apply Bravecto Topical for cats: Step 1: removing the tube from the product pouch, and holding the tube firmly upright you twist the cap of the tube off until you hear the seal breaking. Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. Copyright © 2021 Animalytix LLC. They are available in three weight range packs, with a simple twist-n-use dispensing tube making it quick and easy to use. Additional information can be found at www.bravecto.com. Use with caution in cats that are heartworm positive (see Animal Safety). View Labeling Archives, *ALT was greater than twice the upper reference range of 100 IU/L. The kittens in the control group were administered saline orally. In well-controlled laboratory effectiveness studies, the following adverse reactions were seen after application of Bravecto Plus: pyrexia, tachypnea, mydriasis, pruritus, scabbing, and bloody stool. To make application easier, have your cat … In a pilot oral safety study, adult cats orally administered 0.5× or 1× the maximum labeled dose of Bravecto Plus had foaming hypersalivation for up to five minutes and reduced food consumption on the day of dosing. Use with caution in cats with a history of neurologic disorders. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. No adverse reactions were observed from the concurrent use of Bravecto Plus with other medications. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. Fluralaner is an inhibitor of the arthropod nervous system. Greasy, oily, or wet appearance may occur at the application site in some cats. Kills fleas, ticks, roundworms, hookworms and prevents heartworm disease for 2 months. Do not use directly on any skin lesions. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. Do not store above 77°F (25°C). In foreign market experience reports for Bravecto Plus, one veterinarian experienced tingling and numbness of the fingers, hand, and arm, and swelling of the hand and arm after getting Bravecto Plus on her fingers. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. Step 2: The cat should be standing or lying with its back horizontal during application. A single Bravecto ® Chew treatment lasts for 12 weeks in dogs, while the Spot-On lasts for 4 months for ticks and 6 months for fleas. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. Step 3: Squeeze the tube and gently apply the entire contents of BRAVECTO directly to the skin at the base of the skull of the cat. Clinical signs in one cat in the 1X group included vomiting, depression, vocalization, and ataxia 38 days after dosing. Bravecto for Cats has not been shown to be effective for 12-weeks duration in kittens less than 6 months of age. should be administered the appropriate combination of tubes. Bravecto for Cats; Bravecto for Cats. Bravecto spot-on products are absorbed through your cat’s skin, drying quickly at the application site. For cats and kittens 6 months of age and older per page. Put on gloves. Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. BRAVECTO® PLUS . Available for Android and iOS devices. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. Safety in cats infected with adult heartworm (Dirofilaria immitis): Bravecto Plus was administered topically to cats infected with adult heartworm at 1× or 3× the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg (8 cats per group). Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. (fluralaner and moxidectin topical solution) for Cats. The cap should be rotated clockwise or counter clockwise one full turn. The product is highly flammable. When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. Bravecto for Cats is available in three strengths for use in cats (112.5 mg, 250 mg, and 500 mg fluralaner per tube). Put on gloves. Additional information can be found at www.bravecto.com. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Five of six treated kittens experienced hypersalivation. Put on gloves. The kittens in the control group (0X) were treated with mineral oil. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. & Articles, All Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. Not only is Bravecto ® vet-approved and recommended, but it is also proven to be safe for cats that weigh at least 1,2 kg and for kittens older than 11 weeks. Apply at the base of the skull, to ensure wet product can't be licked. It is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time. Avoid contact with skin and eyes. Keep this and all drugs out of the reach of children. Part the fur at the administration site. Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1× group and 7/8 cats in the 3× group). Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Bravecto ® Plus . This solution seeps into the tissues located beneath the skin, and when fleas and ticks bite, they ingest the solution and die within 8 hours. Single incidences of self-limiting hypersalivation in three kittens (one kitten in the 1× group and two kittens in the 3× group) and pruritus at the administration site in one kitten in the 3× group were observed on the day of dose administration. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. Product may be supplied in 1 or 2 tubes per carton. Bravecto Plus (fluralaner and moxidectin topical solution) for Cats. is this? There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Biochemical Data Summary. The cats in the control group (0×) received mineral oil topically. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. I live in New Zealand I used this on my three cats today. The tube is open and ready for application when a breaking of the seal is felt. In a pilot oral safety study, adult cats orally administered 0.5X or 1X the maximum labeled dose of Bravecto Plus had foaming hypersalivation for up to five minutes and reduced food consumption on the day of dosing. View NDC Code(s)NEW! Percentage of Cats with Adverse Reactions (AR) in the Field Study, Safety in cats infected with adult heartworm (Dirofilaria immitis), All Drug Bravecto Plus - How it works? Each tube is packaged individually in a pouch. These cats also had mild elevations of aspartate aminotransferase (AST) (less than twice the upper reference range of 100 IU/L). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=d9d5ebde-7ff7-4864-b393-fbe77d7a112f, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. Despite this, I obtained a replacement from the store and applied as directed. Store in the original package in order to protect from moisture. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Hold the tube at the crimped end with the cap in an upright position (tip up). Discount flea, tick, heartworm and intestinal worm treatments by PetBucket. Bravecto for Cats kills fleas, prevents flea infestations and kills black-legged ticks for 12 weeks. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. In a European field study for fluralaner topical solution for cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. One stop treatment shop for dogs and cats to prevent nasty parasites from damaging their health. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). Bravecto® works by seeping into the tissues located beneath the skin. Clinical signs in one cat in the 1× group included vomiting, depression, vocalization, and ataxia 38 days after dosing. (fluralaner and moxidectin topical solution) for Cats. Sort By. Avoid oral ingestion. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. 6 Items. Place the tube tip vertically against the skin at the base of the skull of the cat. There are no known contraindications for the use of the product. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. Drug names that are ambiguous or not compatible with the RxNorm system, such as multivitamins with more than 4,000 characters in their names, are also out of scope. In addition, three treated cats (2/8 cats in the 1× group and 1/8 cats in the 3× group) developed adverse neurologic signs during the study and were euthanized due to quality-of-life concerns. is a systemic insecticide and For cats, the spot-on treatment isn’t as water resistant as Frontline’s. In a well-controlled laboratory study, Bravecto Plus killed 100% of fleas within 12 hours after treatment and reduced the numbers of live fleas on cats by >99% within 12 hours after treatment or infestation for 2 months. Select one or more newsletters to continue. Place the tube tip vertically against the skin at the base of the skull of the cat. These adverse events occurred within 48 hours of administration. Advantages NEW BRAVECTO® PLUS (fluralaner and moxidectin topical solution) for Cats is the solution for fleas, ticks, heartworm and intestinal parasites in ONE easy, 2-month topical. Bravecto for Cats requires a prescription from your veterinarian. Bravecto Plus Spot-On is for cats with, or at risk from, mixed parasitic infections by ticks and fleas, gastrointestinal nematodes or heartworm. Part the hair and apply directly to the skin. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/reportanimalae. One treated kitten experienced vomiting 2 hours after administration and another 8 hours after treatment. Avoid contact with skin and eyes. A second cat in the 1X group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. Step 1: Immediately before use, open the pouch and remove the tube. Once administered, the formula spreads throughout the body and results starts to show only within 48 hours. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat’s first seasonal exposure to mosquitoes and continuing until the cat’s last seasonal exposure to mosquitoes. Place the tube tip vertically against the skin at the base of the skull of the cat. If you are a consumer or patient please visit Bravecto for Cats Medium Cats; Bravecto Plus - DO NOT USE. WARNINGS Human Warnings: Not for human use. Use with caution in cats with a history of neurologic disorders. It comprises of two active ingredients: Fluralaner and Moxidectin. Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone, butylhydroxytoluene. Contents: 1 tube containing 250 mg fluralaner and 12.5 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older These adverse events occurred within 48 hours of administration. Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb – 27.5 lb (1.2 kg to 12.5 kg). Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. Single incidences of self-limiting hypersalivation in three kittens (one kitten in the 1X group and two kittens in the 3X group) and pruritus at the administration site in one kitten in the 3X group were observed on the day of dose administration. Treated kittens had reduced food consumption on the day of treatment. Avoid oral ingestion. When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication. PubMed, Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. BRAVECTO PLUS has not been shown to be effective for 2 months in kittens less than 6 months of age. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. One treated kitten experienced vomiting 2 hours after administration and another 8 hours after treatment. For topical use only. Avoid oral ingestion (see Animal Safety). Updated: 2020-12-31. In a well-controlled laboratory study, Bravecto Plus killed 100% of fleas within 12 hours after treatment and reduced the numbers of live fleas on cats by >99% within 12 hours after treatment or infestation for 2 months. Fluralaner is a member of the isoxazoline class. 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