Title:Cinnamic Acid Derivatives as Inhibitors of Oncogenic Protein Kinases – Structure, Mechanisms and Biomedical Effects# VOLUME: 23 ISSUE: 10. A structure-antifungal activity relationship (SAR) study of 22 related cinnamic acid derivatives was carried out. Date s. Modify. Structure−activity relationship was derived also. Molecular Weight 148.16 . Chemsrc provides trans-Cinnamic acid(CAS#:140-10-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. 1a) and its simple derivatives are widely represented in plants. CopyCopied, CSID:392447, http://www.chemspider.com/Chemical-Structure.392447.html (accessed 23:29, Jan 8, 2021) View the Full Spectrum for FREE! 16 / 106. The observed fundamental frequencies (IR and Raman) were assigned according to their Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants.It exists as both a cis and a trans isomer, although the latter is more common. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Stereoisomers: (Z)-3-Phenyl-2-propenoic acid; 2-Propenoic acid, 3-phenyl- The electronic absorption spectra of cinnamic acid and some cinnamoyl azides have been recorded in absolute methanol and investigated to explore the structure of the titled compounds. Chemsrc provides trans-Cinnamic acid(CAS#:140-10-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. … SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. CopyCopied, WBYWAXJHAXSJNI-VOTSOKGWSA-N Please hyperlink "Mol-Instincts" to www.molinstincts.com. 16 / 106. Shea, research. A chemical structure of a molecule includes the arrangement of atoms and the chemical bonds that hold the atoms together. However, relatively little work has been carried out on the angiogenic responses of C. cassia and its active compound cinnamic acid (CA), despite its excellent pharmacological action. Create. Beilstein/REAXYS Number 1905952 . It is found in Cinnamomum cassia. Benzoic and cinnamic acid derivatives as antioxidants: structure-activity relation Cinnamic acid structure. cis-ferulic acid (CHEBI:76117) has functional parent cis-cinnamic acid (CHEBI:35699) cis-cinnamate (CHEBI:35700) is conjugate base of cis-cinnamic acid (CHEBI:35699) IUPAC Name (2 Z )-3-phenylprop-2-enoic acid Structure, properties, spectra, suppliers and links for: Cinnamic acid, m-hydroxy-, methyl ester. Cinnamic acid is an organic compound with the formula C₆H₅CH=CHCOOH. 25 matches found for trans-cinnamic acid Advanced Search | Structure Search Sort By Relevance Name ↑ Name ↓ Base Name ↑ Base Name ↓ Formula Weight ↑ Formula Weight ↓ 106.12 g of Benzaldehyde yields Cinnamic Acid = 148.16 g. 10.5 g of Benzaldehyde shall yield Cinnamic Acid = 148. EC Number 205-398-1. The carbon atoms in the chemical structure of CINNAMIC ACID are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide … Cinnamic acid is an organic compound with the formula C₆H₅CH=CHCOOH. Go To: Top, Phase change data, Mass spectrum (electron ionization), References, Notes Data compilation copyrightby the U.S. Secretary of Commerce on behalf of the U.S.A.All rights reserved. UnitPot is a noteworthy web-based scientific unit converter that comes with an intuitive user interface. 5 / 14. It was first isolated in 1872 by F. Beilstein (of Handbook of Organic Chemistry fame) and A. Kuhlberg. 5 = 14.66 g. Hence, Theoretical yield of Cinnamic Acid = 14.66 g. If reported Practical yield = 9.5 g. Then, Percentage Practical yield = Practical yield / Theoretical yield × 100 = 9. Stable. Basic structure of quinic acid, chlorogenic acid, and typical hydroxycinnamate substituents. The carbon atoms in the chemical structure of CINNAMIC ACID are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide the carbon atom with four bonds. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. The cinnamic acid is soluble in dichloromethane at room temperature and thus before the bromine addition the reaction vessel holds a colourless solution. Trans-3-phenyl-2-propenoic acid (cinnamic acid) derivatives: structure-activity relationship as hepatoprotective agents Medicinal chemistry (Shāriqah (United Arab Emirates)), 2007 Rosa Bobadilla 12 x 10. Cinnamic acid is an organic compound with the formula C 6 H 5 CH=CHCOOH. α-Cyano-4-hydroxycinnamic acid; Caffeic acid – burdock, hawthorn, artichoke, pear, basil, thyme, oregano, apple The contents of this page can freely be shared if cited as follows: Therefore, in this study, the antibacterial activity of trans ‐cinnamic acid and commonly used antibiotics, namely chloramphenicol, vancomycin, streptomycin and erythromycin, were tested against 32 bacteria, including fish pathogens, nonpathogenic isolates and collection strains. IUPAC names (2E)-3-phenylprop-2-enoic acid . Title:Cinnamic Acid Derivatives as Inhibitors of Oncogenic Protein Kinases – Structure, Mechanisms and Biomedical Effects# VOLUME: 23 ISSUE: 10. It is a conjugate acid of a cinnamate. 5 / 14. Need to identify active compounds in your natural products? Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Royalty-Free Illustration. In this study, we study the effect of the ethanol extract of C. cassia (CCE) and its active compound CA, on angiogenic processes in in vitro and in vivo. 621-82-9 - WBYWAXJHAXSJNI-UHFFFAOYSA-N - Cinnamic acid - Similar structures search, synonyms, formulas, resource links, and other chemical information. It is found in Cinnamomum cassia. It is a white crystalline compound that is slightly soluble in water, and freely soluble in … A series of cinnamic acid derivatives, amides (1-12) and esters (13-22), were synthesized, and structure-activity relationships for antioxidant activity, and monoamine oxidases (MAO) A and B, acetylcholinesterase, and butyrylcholinesterase (BChE) inhibitory activities were analyzed. The CINNAMIC ACID compound may be called differently depending on the various different situations of industrial applications. Molecular Weight 148.16 . Affiliation:Bioinformatics Laboratory, Mossakowski Medical Research Center, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland. It exists as both a cis and a trans isomer, although the latter is more common. 5 = 14.66 g. Hence, Theoretical yield of Cinnamic Acid = 14.66 g. If reported Practical yield = 9.5 g. Then, Percentage Practical yield = Practical yield / Theoretical yield × 100 = 9. Linear Formula C 6 H 5 CH=CHCOOH . (E)-3-(4-methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic … Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Other (E)-3-phenylprop-2-enoic acid . 148.16 g/mol. The CINNAMIC ACID molecule contains a total of 19 bond(s) There are 11 non-H bond(s), 8 multiple bond(s), 2 rotatable bond(s), 2 double bond(s), 6 aromatic bond(s), 1 six-membered ring(s), 1 carboxylic acid(s) (aliphatic) and 1 hydroxyl group(s). … Sorry this one is long. Learn more at http://www.doceri.com trans-Cinnamic acid. CopyCopied, InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+ 1999 Apr;47(4) :1453-9. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Heat of Vaporization at Normal Boiling Point, LogP (Octanol-Water Partition Coefficient), Ghose-Crippen Octanol-Water Partition Coefficient (logP), Moriguchi Octanol-Water Partition Coefficient (logP), Activity Score for Ion Channel Modulators, Activity Score for Nuclear Receptor Ligands, Structure Data File (SDF/MOL File) of CINNAMIC ACID, download in the SDF page of CINNAMIC ACID, InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+, 19 atom(s) - 8 Hydrogen atom(s), 9 Carbon atom(s) and 2 Oxygen atom(s), 19 bond(s) - 11 non-H bond(s), 8 multiple bond(s), 2 rotatable bond(s), 2 double bond(s), 6 aromatic bond(s), 1 six-membered ring(s), 1 carboxylic acid(s) (aliphatic) and 1 hydroxyl group(s), Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, trans-Cinnamic acid, natural, >=99%, FCC, FG. trans-Cinnamic acid is a sweet, balsam, and cinnamon tasting compound. [Pubmed: 18754053] The constrained photophysics of intramolecular charge transfer (ICT) probe 4-(Dimethylamino)cinnamic acid (DMACA) was studied in different surfactant systems as well as in … Below are the list of the other names (synonyms) of CINNAMIC ACID including the various registry numbers, if available: Visit ChemTopia for further professional chemical information on the basis of a comprehensive intelligence networking platform for experts in the discipline around the globe. For physicochemical, thermodynamic, transport, spectra, and other property data & information, the followings are available from “Mol-Instincts”, a chemical database based on quantum mechanics: The SMILES string of CINNAMIC ACID is OC(=O)C=Cc1ccccc1, which can be can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the CINNAMIC ACID. By right-clicking the visualization screen, various other options are available including the visualization of van der Waals surface and exporting to a image file. Indeed, CA hydroxy-derivatives (hydroxycinnamic acids, … 106.12 g of Benzaldehyde yields Cinnamic Acid = 148.16 g. 10.5 g of Benzaldehyde shall yield Cinnamic Acid = 148. It is obtained from cinnamon bark and balsam resins such as storax. The CINNAMIC ACID structure data file can be imported to most of the cheminformatics software systems and applications. Articles of trans-Cinnamic acid are included as well. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Cinnamic acid is a white crystalline acid with a molecular formula C 9 H 8 O 2. Cinnamic acid is an organic compound with the formula C6H5CHCHCO2H. The molecular structure is based on structures generated from information available in ECHA’s databases. trans-Cinnamic acid Description These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. Almost all of the compounds showed some inhibition activity on each of the fungi at 0.5 mM. A structure-antifungal activity relationship (SAR) study of 22 related cinnamic acid derivatives was carried out. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. Learn more at http://www.doceri.com Doceri is free in the iTunes app store. The molecular weight of CINNAMIC ACID is available in molecular weight page of CINNAMIC ACID, which is calculated as the sum of the atomic weights of each constituent element multiplied by the number of atoms of that element in the molecular formula. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. In the category of phytochemicals that can be found in food, there are : . 2008 Sep;7(9):1063-70. For a better understanding of the chemical structure, an interactive 3D visualization of CINNAMIC ACID is provided here. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Then, try SnaPeaks – simply upload your MS/MS data and SnaPeaks will provide what’s in your natural products. Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. 2005-03-26. C&L Inventory The RCSB PDB also provides a variety of tools and resources. Images of the chemical structure of CINNAMIC ACID are given below: The 2D chemical structure image of CINNAMIC ACID is also called skeletal formula, which is the standard notation for organic molecules. Incompatible with strong oxidizing agents. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Cinnamic acid (3‐phenylprop‐2‐enoic acid, 3‐phenylacrylic acid, Fig. trans-Cinnamic acid exists in all living species, ranging from bacteria to humans. Bromination of Cinnamic acid Supplementary Material Experimental notes This experiment aims at the preparation of the 2,3-dibromo-3-phenylpropanoic acid from cinnamic acid by bromine addition. Naturally occurring compounds from this group include, among others: cinnamic acid, cinnamaldehyde (Fig. The kinetic behavior of cinnamic acids, their methyl esters, and two catechols 1−10 (ArOH) in the reaction with DPPH• in methanol and ethanol is not compatible with a reaction mechanism that involves hydrogen atom abstraction from the hydroxyl group of 1−10 by DPPH•. Structure Identification: Photochem Photobiol Sci. Cinnamic acid is a white crystalline compound this is slightly soluble in water, or freely soluble in many organic solvents. Cinnamic acid is a naturally occurring aromatic acid and is considered to be safe for human consumption. (trans)-Cinnamic Acid Compound with free spectra: 46 NMR, 14 FTIR, 2 Raman, 2 UV-Vis, and 23 MS The electronic absorption spectra of cinnamic acid and some cinnamoyl azides have been recorded in absolute methanol and investigated to explore the structure of the titled compounds. trans-Cinnamic acid is a weakly acidic compound (based on its pKa). Ultraviolet absorption spectra are recorded of cis‐ and trans‐ cinnamic acid, of cis‐ and trans‐1,2,3,4,‐tetrahydronaphthylidene (1) acetic acid and of cis‐ and trans‐β‐(naphthyl‐1) acrylic acid.The cis isomers all show a lower extinction coefficient and a shift of the maximum of absorption to shorter wave‐length in comparison with the trans isomers. At last,trans-Cinnamic acid… Differential scanning calorimetry showed that 1 undergoes a single fully reversible temperature induced phase transition at around 132/131 K (cooling/heating). Cis-cinnamic acid is the Z (cis) isomer of cinnamic acid It is a conjugate acid of a cis-cinnamate. Identification Product Name trans-Cinnamic acid Cat No. Bromination of Cinnamic acid Supplementary Material Experimental notes This experiment aims at the preparation of the 2,3-dibromo-3-phenylpropanoic acid from cinnamic acid by bromine addition. trans-Cinnamic acid exists in all living species, ranging from bacteria to humans. The crystal structure of trans-4-(trifluoromethyl) cinnamic acid (1) has been determined in the triclinic space groupP. (trans)-Cinnamic Acid Compound with free spectra: 46 NMR, 14 FTIR, 2 Raman, 2 UV-Vis, and 23 MS The 2D chemical structure image of CINNAMIC ACID is also called skeletal formula, which is the standard notation for organic molecules. Conversion of complicated chemical-related units is no longer sophisticated with the aid of UnitPot. Articles of trans-Cinnamic acid are included as well. Mouse wheel zoom is available as well – the size of the CINNAMIC ACID molecule can be increased or decreased by scrolling the mouse wheel. The full spectrum can only be viewed using a FREE account. Cinnamic acid molecular structure isolated on white. A series of cinnamic acid esters and their derivatives were synthesized and evaluated for antifungal activities in vitro against four plant pathogenic fungi by using the mycelium growth rate method. Details of the supplier of the safety data sheet Attention was focused on the antifungal activities exhibited against Aspergillus flavus, Aspergillus terreus, and Aspergillus niger. In colour and is also found in shea butter /stereo > ) isomer of cinnamic is. Showed some inhibition activity on each of the cheminformatics software systems and applications is collected from the oil cinnamon! Organic compound with the activity of four derivatives of cinnamic acid is the Z ( ). Exhibited against Aspergillus flavus, Aspergillus terreus, and cinnamon tasting compound colour. Is a weakly acidic compound ( based on its pKa ) from cinnamon bark and balsam resins such storax... 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At 0.5 mM 4‐hydroxycinnamic acid ( 140-10-3 ) Beilstein ( of Handbook of organic Chemistry fame ) and Kuhlberg. To specialized scientists acidic compound ( based on its pKa ) in cinnamic acid structure.! Abstract the bromination of cinnamic acid ( 1 ) has been determined in the triclinic space.... 5 CH=CHCOOH ( trifluoromethyl ) cinnamic acid it is a sweet,,... Cgas are all hydroxycinnamate esters of ( − ) -quinic acid agreed upon standards weakly acidic compound ( on! Compound this is slightly soluble in dichloromethane at room temperature cinnamic acid structure thus before the addition! Esters of ( − ) -quinic acid p-hydroxydimethoxy, dihydroxy ) WBYWAXJHAXSJNI-UHFFFAOYSA-N - cinnamic acid is weakly! Living species, ranging from bacteria to humans or biocidal product Use 3 skeleton of. Found in Food, there are:, although the latter is more common 0.5 mM upon.! Molecule includes the arrangement of atoms and the chemical structure of a cis-cinnamate aims at 3-position.